The scientists demonstrated in cell culture studies that human ovarian cancer cells resistant to platinum drugs became up to 6 times more sensitized to the drugs after exposure to the cranberry compounds in comparison to cells that were not exposed to the compounds which were obtained from juice extracts.
Although preliminary the findings undergo the potential to save lives and reduce the harmful side effects associated with using high doses of platinum drugs for the treatment of ovarian cancer the researchers say adding that human studies are comfort needed. The new chew over adds to a growing number of potential health benefits linked to cranberries.
"For the first time we undergo shown in our in vitro studies that cranberry extracts can alter resistant human ovarian cancer cell lines," say study co-presenters Ajay P. Singh. Ph. D. and Nicholi Vorsa. Ph. D. natural products chemists at Rutgers University. "This has opened up exciting possibilities for therapeutic intervention associated with platinum therapy," add Singh and Vorsa who collaborated with colleagues Laurent Brard. M. D.. Ph. D. Rakesh K. Singh and K. S. Satyan. Ph. D. of cook University.
But the researchers warn that the study is experimental and that patients with ovarian cancer should always consult with their physicians before trying any type of anti-cancer therapy. Ovarian cancer is the seventh most common cancer and the fifth leading cause of cancer death among women in the United States according to the Centers for Disease hold back and Prevention.
Chemotherapy using platinum drugs including cisplatin and paraplatin is a mainstay treatment for ovarian cancer. However cancer cells tend to develop resistance to platinum therapy and higher doses of the drugs can create unwanted side-effects including nerve damage and kidney failure.
The new study focused on cranberry juice because of past investigate suggesting that the juice has a wide range of potential health benefits including the ability to contend urinary tract infections digest ulcers and cancer. Singh and his associates obtained ovarian cancer cells that were relatively resistant to platinum. They treated the cells with various doses of a purified extract of commercially available cranberry consume (containing 27 percent pure juice) exposed the cells to the platinum medicate paraplatin and compared them to cells that were not exposed to the remove.
Paraplatin killed 6 times more cancer cells that were pre-treated with juice extract compared to cells that were exposed to the cancer medicate alone the researchers say. The remove also slowed the growth and move of some cancer cells. The maximum amount of juice remove given to the cells was the human equivalent of about a cup of cranberry juice according to the researchers.
Singh and colleagues believe that the active compounds in the remove are powerful antioxidants called A-type proanthocyanidins that are unique to cranberries and not found in other fruits. The researchers add that they do not understand exactly how the cranberry compounds work. However based on research by other groups these compounds appear to attach to and block certain tumor promoter proteins found in the ovarian cancer cells they say. The prove is that the cancer cells change state more vulnerable to attack from the platinum drugs the scientists say noting that the cranberry compounds are not a aid for cancer.
The researchers hope to eventually determine the most active anti-cancer fractions of the cranberry extract and cause the optimal process for effectiveness against ovarian cancer. Theoretically a therapeutic compound made from cranberry remove could be used as move of an injectable chemotherapy regimen or as a beverage add to be consumed during chemotherapy says Singh. Animal studies will mouth soon and a new therapy could one day be available to consumers if advance testing proves successful he says.
For now the researchers advise that those with ovarian and other types of cancer seek their physician's advice for the most effective treatment options. The current chew over was funded by the National Institutes of Health and the Rutgers New Jersey Agricultural investigate Station.
Cruise 4 Cash -
Detective Sherlock -
Free Bid Auctions -
Expert Poker Tips -
Shop 4 Money
Win Any Lottery -
Repo Car Search -
Psychics 4 Free -
High Quality Games -
Driving 4 Dollars
Related article:
http://www.news-medical.net/?id=28955
comments | Add comment | Report as Spam
|
